Blog

Methods companion to the TERT promoter post: notebook setup, gnomAD control selection, model choice, AlphaGenome API calls, score_variant caveats and evaluation against published biology.

A deep-dive into TERT promoter mutations using AlphaGenome to reconstruct chromatin, TF binding and transcriptional effects from sequence alone.

A practical tool to check whether your tissue or cell type is covered in AlphaGenome training tracks before you run variant effect analyses.

U-Net DNA, teacher–student distillation, 5,930 tracks, GWAS to T-ALL: how AlphaGenome compresses a megabase, attends globally and scores variants, plus how to run it.

From a missing pancreas to cis-regulatory logic: why most disease variants sit outside genes and the range-versus-resolution problem AlphaGenome was built to solve.

A data-driven analysis of AI augmentation potential across computational biology and life sciences, using Anthropic's labor market data, 176 job descriptions and a live test on my own role.

What I learned building agents for the past two years. A practical guide to the frameworks, tools and patterns that actually work.

I'm excited to share insights about AI, genomics and research. This is the beginning of a journey to document my learnings and discoveries.